From Baltimore & Washington, DC:

Take Route 50 East to Route 90 East.
Take Route 589 South towards Ocean Pines.
At second intersection (Ocean Pines South Gate) turn left onto Manklin Creek Road.
Take second right onto Ocean Parkway.
After 1/4 mile, turn left onto Central Parke West,  the main entrance of The Parke.

From DE, NJ, NY & PA:

Take I-95 to Route 13 South to Route 113 South.
Take Exit for Route 589 South.
After intersection with Route 90 overpass, take the second left at Ocean Pines South Gate onto Manklin Creek Road. 
Take second right onto Ocean Parkway.
After 1/4 mile, turn left onto Central Parke West, the main entrance of The Parke.